SEEMA PURI, GOBIND RAM, YADVINDRA SINGH, GULAB SINGH, CHANDER PARKASH, ANIL KUMAR AND SHIV KUMAR GIRI*
Department of Biotechnology, School of Basic and Applied Sciences, Maharaja Agrasen University, Baddi,
Solan-174 103 (Himachal Pradesh), India
*(e-mail: goswamishiv@gmail.com; Mobile: 85720 49078)
(Received: November 20, 2025; Accepted: December 25, 2025)
ABSTRACT
Ventricular heart arrhythmia (VHAD) is a life-threatening cardiac disorder often associated with sudden cardiac death, underscoring the need for safer and more effective therapeutic alternatives. In this study, phytochemicals from Cinnamomum verum, a renewable and environmentally sustainable botanical resource, were investigated for their potential to modulate the N-terminal region of the ryanodine receptor 2 (RyR2), a key regulator of intracellular calcium release implicated in arrhythmogenic pathways. More than 40 phytochemicals were identified and evaluated using an eco-friendly, fully in silico workflow that involved molecular modelling, virtual screening and molecular docking. Among the screened compounds, Cinnzeylanol exhibited the most favourable binding affinity (“7.8 kcal/mol) and strong conventional hydrogen bonding with critical RyR2 n-terminal residues, having role in pathogenesis. These findings provide potential evidence for the therapeutic promise of natural lead molecule from C. verum for controlling aberrant calcium signalling associated with VHA.
Key words: Ventricular heart arrhythmia, drug likeliness, binding affinity, pharmacokinetic properties