JYOTIKA VATS, AMIT AND AMIT KUMAR*
Department of Biotechnology, Keral Verma Subharti College of Science, Swami Vivekanand Subharti University,
Meerut-250 005 (Uttar Pradesh), India
*(e-mail: amit.agbiotech1581@gmail.com; Mobile: 95571 05093); ORCID: https://orcid.org/0000-0003-3594-
5103
(Received: November 8, 2025; Accepted: December 20, 2025)
ABSTRACT
The immunomodulatory properties of Moringa oleifera and Mentha spicata are of great interest because of their ability to enhance immunity, suppress inflammation, and protect against viruses and other pathogens. This study presented a discussion of the mechanisms involved with M. oleifera enhancing immunity through its effects on white blood cell and lymphocyte production as well as modulatory effects on cytokines. Simultaneously, the anti-inflammatory and antimicrobial properties of M. spicata were discussed with particular reference to the active ingredients in its essential oils, polyphenols and terpenes that altered immune function. Both herbs had synergistic mechanisms to alter immune function, with Moringa enhancing the immune response and Mentha modulating the inflammatory response. Pre-clinical studies suggested immune-modulating properties indicative of clinical potential as therapeutic interventions to address infection, autoimmunity and immunosuppression, while larger clinical research studies needed to be conducted to support any of the results. The combination of these plants had promise as an adjunct immunotherapy for the development of safer, natural alternatives to synthetic immunomodulators for use in the context of personalised medicine and integrative health care models. The current research article underscored the necessity for further investigation to enhance the comprehension of the immunomodulating capabilities of these natural products in diverse populations.
Key words: Antioxidant, cytokine, immunomodulators, Moringa oleifera, Mentha spicata